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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NF1
All Species:
22.73
Human Site:
Y182
Identified Species:
50
UniProt:
P21359
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21359
NP_000258.1
2839
319372
Y182
H
D
I
E
L
L
Q
Y
I
N
V
D
C
A
K
Chimpanzee
Pan troglodytes
XP_511395
2839
319368
Y182
H
D
I
E
L
L
Q
Y
I
N
V
D
C
A
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537738
2824
317549
A171
Q
Y
I
N
V
D
C
A
K
L
K
R
L
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q04690
2841
319577
Y182
H
D
I
E
L
L
Q
Y
I
N
V
D
C
A
K
Rat
Rattus norvegicus
P97526
2820
317065
Y182
H
D
I
E
L
L
Q
Y
I
N
V
D
C
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506475
2851
320923
Y193
H
D
I
E
L
L
Q
Y
I
N
V
D
C
A
K
Chicken
Gallus gallus
XP_415914
2833
319514
Y182
H
D
I
E
L
L
Q
Y
I
S
V
D
C
S
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692937
2750
310306
E169
Q
E
L
T
V
C
S
E
D
T
V
D
V
H
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001014668
2764
312956
H182
N
D
I
E
L
I
Q
H
I
D
M
D
M
I
K
Honey Bee
Apis mellifera
XP_624747
2748
312616
H190
S
D
I
E
L
I
Q
H
I
N
V
D
V
C
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001197154
1913
215693
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
98.8
N.A.
98.4
97.8
N.A.
95.3
95.2
N.A.
85.6
N.A.
55.5
56
N.A.
40.3
Protein Similarity:
100
100
N.A.
99.1
N.A.
99.3
98.6
N.A.
97.4
97.8
N.A.
91.3
N.A.
71.2
71.6
N.A.
52.3
P-Site Identity:
100
100
N.A.
13.3
N.A.
100
100
N.A.
100
86.6
N.A.
13.3
N.A.
53.3
66.6
N.A.
0
P-Site Similarity:
100
100
N.A.
20
N.A.
100
100
N.A.
100
100
N.A.
33.3
N.A.
86.6
80
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
0
46
0
% A
% Cys:
0
0
0
0
0
10
10
0
0
0
0
0
55
10
0
% C
% Asp:
0
73
0
0
0
10
0
0
10
10
0
82
0
0
10
% D
% Glu:
0
10
0
73
0
0
0
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
55
0
0
0
0
0
0
19
0
0
0
0
0
10
0
% H
% Ile:
0
0
82
0
0
19
0
0
73
0
0
0
0
10
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
82
% K
% Leu:
0
0
10
0
73
55
0
0
0
10
0
0
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% M
% Asn:
10
0
0
10
0
0
0
0
0
55
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
19
0
0
0
0
0
73
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
10
0
0
0
0
0
10
0
0
10
0
0
0
10
0
% S
% Thr:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% T
% Val:
0
0
0
0
19
0
0
0
0
0
73
0
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
55
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _